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DHEA mechanism as antidepressant may act via modulation on the GABAARs activity. The GABA ergic system can mediate depression (Lloyd et aliae, 1989). In depressed patients, cerebral cerebrospinal fluid levels of GABA are below in healthy controls (Gerner and Hare, 1981; Gold et aliae, 1980). Furthermore, low GABA content is correlated with depression in post mortem temporal and frontal cortices from patients with Alzheimer’s disease (Garcia Alloza et al., 2006). Through these patients rs gold, a high density of GABAARs correlates with the harshness of depression. Rapidly increased cortical concentration of GABA upon antidepressant management of healthy individuals (Bhagwagar et alii, 2004) and electroconvulsive therapy for depressed patients (Sanacora et alibi, 2003), anti depressants that affect GABA have yet to be developed. The subunit composition determines the pharmacological properties of GABAAR.